ODCs

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2 OMIM references -
2 associated genes
7 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 2

1 OMIM reference -
1 associated gene
24 signs/symptoms

Isolated trigonocephaly

Deafness with labyrinthine aplasia, microtia, and microdontia

FGFR1	(UniProt - OMIM)		FGF3	(UniProt - OMIM)
FREM1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	FGFR1	(0.52)	FGF3

Citations in the biomedical literature:

Isolated trigonocephaly		Deafness with labyrinthine aplasia, microtia, and microdontia
	Synonym(s): - Non-syndromic metopic craniosynostosis		Synonym(s): - LAMM syndrome - Microdontia - type I microtia - deafness

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare genetic disease - Rare otorhinolaryngologic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive

	External references: 2 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C548011


COMMON SIGNS	- Broad nasal root - Synophris / synophrys

Isolated trigonocephaly		Deafness with labyrinthine aplasia, microtia, and microdontia
	Very frequent - Autosomal dominant inheritance - Trigonocephaly Frequent - Hypotelorism - Prominent supraorbital ridge Occasional - Omphalocele / exomphalos		Very frequent - Abnormal dentition / dental position / implantation / unerupted / dental ankylosis - Autosomal recessive inheritance - Complete / partial microdontia - Cranial nerve anomalies - Microtia / cryptomicrotia / anotia / external auditory canal / pinnae aplasia / hypoplasia - Sensorineural deafness / hearing loss - Structural anomalies of inner ear / cochlea / vestible / semicircular canals - Tooth shape anomaly Frequent - Downslanted palpebral fissures / anti-mongoloid slanting palpebral fissures - Long face - Micrognathia / retrognathia / micrognathism / retrognathism - Pointed chin - Small / triangular nares / nostrils Occasional - Anodontia / oligodontia / hypodontia - Bifid / cleft ear lobe / ear lobe pits - Hypermetropia - Hypertelorism - Long / large / bulbous nose - Preauricular / branchial tags / appendages - Strabismus / squint - Supernumerary teeth / polyodontia - Tall stature / gigantism / growth acceleration